SGCA

Across TCGA patient cohorts, SGCA protein abundance is significantly associated with the RNA expression of many other genes, with 3,265 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SGCA-associated genes across cancer lineages are ASB2, SLC8A3, and TCL1A. Each is linked with SGCA in more than 1 cancer types. Because this analysis shows association rather than direction, both SGCA-to-partner and partner-to-SGCA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SGCA versus ASB2 in HNSC, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGCA→partner) and Y-score (partner→SGCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ASB2 →	+0.783	+0.739	.003	.002	3	1
HNSC	SLC8A3 →	+0.675	+0.993	<.001	<.001	3	1
HNSC	TCL1A →	+0.894	+0.612	.003	.008	3	1
HNSC	DOK5 →	+0.574	+0.840	.006	<.001	3	1
HNSC	EEF1A2 →	+1.107	+0.686	<.001	<.001	3	1
HNSC	MYLK2 →	+1.143	+0.739	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,265 associations by consensus.

SGCA vs ASB2 — HNSC

Explore this scatter interactively →