SGCA

Across TCGA patient cohorts, SGCA mutation is significantly associated with the RNA expression of many other genes, with 2,341 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGCA-associated genes across cancer lineages are RNU4-84P, POTEC, and MIR610. Each is linked with SGCA in more than 2 cancer types. Because this analysis shows association rather than direction, both SGCA-to-partner and partner-to-SGCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-84P grouped by SGCA-low versus SGCA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGCA→partner) and Y-score (partner→SGCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU4-84P →	+0.087	+3.990	<.001	.009	3	3
LUAD	POTEC →	+0.159	+4.481	<.001	.005	3	2
LUAD	MIR610 →	+0.457	+4.798	<.001	.006	3	2
LUAD	RN7SL741P →	+0.593	+5.198	<.001	.001	3	2
LUAD	RN7SL55P →	+0.704	+4.194	<.001	.009	3	2
SKCM	TAS1R2 →	+0.014	+3.007	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,341 associations by consensus.

RNU4-84P by SGCA expression — SKCM

Explore this box plot interactively →