SGCA

Across TCGA cell cohorts, SGCA RNA expression is significantly associated with the go_rna of many other GO terms, with 2,525 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SGCA-associated GO terms across cancer lineages are Positive regulation of blood pressure by epinephrine-norepinephrine, Actin filament depolymerization, and Actin polymerization or depolymerization. Each is linked with SGCA in more than 5 cancer types. Because this analysis shows association rather than direction, both SGCA-to-partner and partner-to-SGCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of blood pressure by epinephrine-norepinephrine grouped by SGCA-low versus SGCA-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SGCA→partner) and Y-score (partner→SGCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of blood pressure by epinephrine-norepinephrine →	+0.550	+0.627	.002	.005	3	6
SKIN	Actin filament depolymerization →	+0.158	+0.949	<.001	<.001	3	6
LIVER	Actin polymerization or depolymerization →	+0.126	+2.315	.008	.008	3	5
KIDNEY	Positive regulation of actin filament-based movement →	+0.369	+0.676	.009	.002	3	5
BONE	Collagen fibril organization →	+0.372	+0.663	<.001	.003	3	5
SKIN	Regulation of skeletal muscle contraction →	-0.123	-0.768	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,525 associations by consensus.

Positive regulation of blood pressure by epinephrine-norepinephrine by SGCA expression — BONE

Explore this box plot interactively →