Across TCGA patient cohorts, SFXN4 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFXN4-associated genes across cancer lineages are Annexin-1, Shc_pY317, and STAT3_pY705. Each is linked with SFXN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SFXN4-to-partner and partner-to-SFXN4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFXN4→partner) and Y-score (partner→SFXN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.749	+2.827	.004	.035	3	1
UCEC	Shc_pY317 →	-0.219	-2.321	.004	.035	3	1
UCEC	STAT3_pY705 →	-0.311	-2.321	.018	.035	3	1
UCEC	ATM →	-0.504	-3.000	.027	.036	3	1
SKCM	HER3 →	+0.499	+2.824	.046	.036	1	1
UCEC	c-Jun_pS73 →	-0.214	-2.321	.007	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

SFXN4 survival (RNA) · tumor vs normal (RNA) · all SFXN4 data types