SFTPA1

Across TCGA patient cohorts, SFTPA1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFTPA1-associated genes across cancer lineages are Ku80, MAPK_pT202_Y204, and mTOR_pS2448. Each is linked with SFTPA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SFTPA1-to-partner and partner-to-SFTPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by SFTPA1-low versus SFTPA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFTPA1→partner) and Y-score (partner→SFTPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.265	+2.817	.020	.036	3	1
UCEC	MAPK_pT202_Y204 →	-0.502	-3.000	.027	.036	3	1
UCEC	mTOR_pS2448 →	-0.156	-3.156	.030	.018	3	1
UCEC	Rab25 →	-0.451	-3.169	.004	.018	3	1
UCEC	Annexin-1 →	+0.662	+3.019	.009	.019	3	1
UCEC	VHL →	-1.339	-2.459	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Ku80 by SFTPA1 expression — UCEC

Explore this box plot interactively →