SFRP4

Across TCGA patient cohorts, SFRP4 mutation is significantly associated with the RNA expression of many other genes, with 1,828 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFRP4-associated genes across cancer lineages are IGKV3-34, TUBGCP5, and UHRF1. Each is linked with SFRP4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SFRP4-to-partner and partner-to-SFRP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGKV3-34 grouped by SFRP4-low versus SFRP4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFRP4→partner) and Y-score (partner→SFRP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IGKV3-34 →	+0.137	+4.306	<.001	<.001	3	3
UCEC	TUBGCP5 →	+0.496	+3.280	<.001	<.001	3	2
UCEC	UHRF1 →	+0.957	+4.332	<.001	<.001	3	2
UCEC	TANGO6 →	+0.531	+2.584	<.001	.001	3	2
HNSC	DDX28 →	+0.514	+3.339	<.001	.005	3	2
READ	RNU6-940P →	+0.232	+4.681	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,828 associations by consensus.

IGKV3-34 by SFRP4 expression — COAD

Explore this box plot interactively →