SFRP4

Across TCGA cell cohorts, SFRP4 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SFRP4-associated genes across cancer lineages are C6orf118, ASCL3, and GYPB. Each is linked with SFRP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SFRP4-to-partner and partner-to-SFRP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by SFRP4-low versus SFRP4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFRP4→partner) and Y-score (partner→SFRP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.096	+3.115	.002	.004	3	1
LARGE_INTESTINE	ASCL3 →	+0.162	+3.617	<.001	.004	3	1
LARGE_INTESTINE	GYPB →	+0.058	+3.562	<.001	.002	3	1
LARGE_INTESTINE	CACNG3 →	+0.003	+3.217	<.001	.006	3	1
LARGE_INTESTINE	KCNK12 →	+0.201	+3.472	.006	.005	2	1
LARGE_INTESTINE	ASPN →	+0.040	+3.426	.002	.007	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

C6orf118 by SFRP4 expression — LARGE_INTESTINE

Explore this box plot interactively →