SFRP2

Across TCGA patient cohorts, SFRP2 mutation is significantly associated with the RNA expression of many other genes, with 551 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFRP2-associated genes across cancer lineages are RNU6-939P, RPS29P26, and RNU6-751P. Each is linked with SFRP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SFRP2-to-partner and partner-to-SFRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-939P grouped by SFRP2-low versus SFRP2-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFRP2→partner) and Y-score (partner→SFRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	RNU6-939P →	+0.279	+7.939	<.001	.008	3	2
LUAD	RPS29P26 →	+0.348	+7.930	<.001	.008	3	2
LUAD	RNU6-751P →	+0.518	+7.930	<.001	.008	3	2
LUAD	RNU6-165P →	+0.528	+7.930	<.001	.008	3	2
UCEC	OR2AP1 →	+0.043	+3.115	.004	.007	3	2
UCEC	MIR615 →	+0.432	+3.039	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 551 associations by consensus.

RNU6-939P by SFRP2 expression — PRAD

Explore this box plot interactively →