SFRP2

Across TCGA pan-cancer cohorts, SFRP2 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SFRP2 data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SFRP2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SFRP2 expression acts as an unfavorable survival marker, although some lineages such as LGG and LUAD show a favorable association.

KIRP, LGG, and BLCA are the cancer types where SFRP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.886	0.974	<.001	107	view →
LGG	OS	Median	All	0.919	0.697	<.001	54	view →
BLCA	OS	Quartile	All	0.329	0.671	<.001	37	view →
HNSC	OS	Tertile	II,III,IV	0.581	0.816	.003	32	view →
LIHC	OS	Quartile	All	0.401	0.709	<.001	31	view →
OV	DFS	Tertile	All	0.489	0.604	.015	30	view →
COAD	DFS	Quartile	All	0.310	0.591	.019	16	view →
ACC	OS	Quartile	IV	0.337	0.876	.006	14	view →
KIRC	DFS	Tertile	All	0.838	0.925	.006	13	view →
LUAD	DFS	Tertile	II,III,IV	0.587	0.360	.031	10	view →
DLBC	DFS	Median	III,IV	1.000	0.525	.013	10	view →
MESO	DFS	Tertile	IV	0.763	0.381	.022	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SFRP2–KIRP (OS)

Open the KIRP breakdown →