SFRP2

Across TCGA patient cohorts, SFRP2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFRP2-associated genes across cancer lineages are Caspase-7-cleavedD198, Notch1, and STAT3_pY705. Each is linked with SFRP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SFRP2-to-partner and partner-to-SFRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SFRP2-low versus SFRP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFRP2→partner) and Y-score (partner→SFRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.849	+3.019	.009	.019	3	2
UCEC	Notch1 →	+0.234	+3.013	.002	.018	3	1
UCEC	STAT3_pY705 →	-0.481	-3.169	<.001	.020	3	1
UCEC	Tuberin_pT1462 →	+0.313	+2.817	.013	.036	2	2
UCEC	MEK1 →	+0.568	+3.169	.004	.020	1	2
UCEC	Tuberin →	+0.380	+3.169	.010	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Caspase-7-cleavedD198 by SFRP2 expression — UCEC

Explore this box plot interactively →