SFRP2

Across TCGA cell cohorts, SFRP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 820 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SFRP2-associated GO terms across cancer lineages are Maintenance of protein localization in organelle, Cotranslational protein targeting to membrane, and Post-translational protein targeting to endoplasmic reticulum membrane. Each is linked with SFRP2 in more than 5 cancer types. Because this analysis shows association rather than direction, both SFRP2-to-partner and partner-to-SFRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maintenance of protein localization in organelle grouped by SFRP2-low versus SFRP2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SFRP2→partner) and Y-score (partner→SFRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Maintenance of protein localization in organelle →	+0.092	+1.014	<.001	.001	3	6
CNS	Cotranslational protein targeting to membrane →	+0.062	+1.625	.001	.003	3	6
LARGE_INTESTINE	Post-translational protein targeting to endoplasmic reticulum membrane →	+0.065	+0.046	<.001	.002	3	5
LUNG_NSCLC_LUAD	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum →	+0.067	+0.035	<.001	<.001	2	6
SOFT_TISSUE	Lactate metabolic process →	+0.093	+1.525	.001	.003	3	4
BONE	Regulation of dermatome development →	+1.400	+2.938	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 820 associations by consensus.

Maintenance of protein localization in organelle by SFRP2 expression — SOFT_TISSUE

Explore this box plot interactively →