SFR1

Across TCGA patient cohorts, SFR1 mutation is significantly associated with the RNA expression of many other genes, with 846 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFR1-associated genes across cancer lineages are RNVU1-28, NUDT4B, and RNU6-1155P. Each is linked with SFR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SFR1-to-partner and partner-to-SFR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNVU1-28 grouped by SFR1-low versus SFR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFR1→partner) and Y-score (partner→SFR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNVU1-28 →	+0.793	+2.050	<.001	.007	3	2
UCEC	NUDT4B →	+0.059	+3.299	<.001	.001	3	2
UCEC	RNU6-1155P →	+0.122	+4.475	.002	.003	3	2
UCEC	RN7SKP264 →	+0.252	+2.503	<.001	.004	3	2
UCEC	TCP11X3P →	+0.281	+2.743	<.001	<.001	3	2
CESC	UBE2V1P4 →	+0.134	+5.103	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 846 associations by consensus.

RNVU1-28 by SFR1 expression — UCEC

Explore this box plot interactively →