Across TCGA pan-cancer cohorts, SFPQP1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of SFPQP1’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where SFPQP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SFPQP1 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
COAD and KIRC are the cancer types where SFPQP1 tumor–normal differential expression is most reproducible.