SFPQ

Across TCGA patient cohorts, SFPQ mutation is significantly associated with the RNA expression of many other genes, with 1,117 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFPQ-associated genes across cancer lineages are RNU6-92P, RNU6-1066P, and TRAJ52. Each is linked with SFPQ in more than 1 cancer types. Because this analysis shows association rather than direction, both SFPQ-to-partner and partner-to-SFPQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-92P grouped by SFPQ-low versus SFPQ-high in KIRP.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFPQ→partner) and Y-score (partner→SFPQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	RNU6-92P →	+0.459	+5.016	<.001	.002	3	2
LUAD	RNU6-1066P →	+0.819	+7.930	<.001	.008	3	2
UCEC	TRAJ52 →	+0.502	+1.756	<.001	.003	3	2
UCEC	IGHD2-2 →	+1.129	+2.097	<.001	<.001	3	2
CESC	RBM22P1 →	+0.024	+4.569	<.001	.005	3	2
BRCA	LINC02549 →	+0.271	+5.291	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,117 associations by consensus.

RNU6-92P by SFPQ expression — KIRP

Explore this box plot interactively →