SFN

Across TCGA pan-cancer cohorts, SFN mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SFN data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SFN mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SFN expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, GBM, and UCEC are the cancer types where SFN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.910	0.783	.007	38	view →
GBM	OS	Median	All	0.387	0.663	<.001	34	view →
UCEC	OS	Median	All	1.000	0.899	.004	16	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	11	view →
LUAD	DFS	Quartile	All	0.386	0.814	.023	7	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.763	.007	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SFN–HNSC (OS)

Open the HNSC breakdown →