SFN

Across TCGA pan-cancer cohorts, SFN RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SFN’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SFN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SFN is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

THCA, UCEC, and LIHC are the cancer types where SFN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SFN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+4.548	<.001	11	view →
UCEC	All	III,IV	+5.922	<.001	8	view →
LIHC	Male	II,III,IV	+4.167	<.001	8	view →
KICH	Female	II,III,IV	−3.567	<.001	8	view →
LUSC	Male	All	+2.844	<.001	8	view →
LUAD	Female	III,IV	+2.460	<.001	6	view →
CHOL	Male	All	+6.568	<.001	5	view →
COAD	Male	All	−0.752	.004	5	view →
PAAD	Female	All	+4.855	.017	4	view →
KIRP	All	All	+2.132	.001	4	view →
HNSC	All	All	+1.317	.001	4	view →
KIRC	All	III,IV	−0.922	.009	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SFN–THCA

Open the THCA breakdown →