SFN

Across TCGA patient cohorts, SFN protein abundance is significantly associated with the RNA expression of many other genes, with 16,732 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SFN-associated genes across cancer lineages are MPZL2, ANXA2, and CDCP1. Each is linked with SFN in more than 7 cancer types. Because this analysis shows association rather than direction, both SFN-to-partner and partner-to-SFN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SFN versus MPZL2 in HNSC, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFN→partner) and Y-score (partner→SFN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MPZL2 →	+1.152	+1.081	<.001	<.001	3	8
HNSC	ANXA2 →	+0.894	+0.927	.001	<.001	3	7
OV	CDCP1 →	+1.127	+0.941	.003	.008	3	6
HNSC	PERP →	+1.228	+1.391	<.001	<.001	3	6
LSCC	KRT16 →	+3.234	+0.919	<.001	<.001	3	6
LSCC	SH3RF2 →	+1.088	+0.799	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,732 associations by consensus.

SFN vs MPZL2 — HNSC

Explore this scatter interactively →