SFN

Across TCGA patient cohorts, SFN mutation is significantly associated with the RNA expression of many other genes, with 3,806 significant associations in total. COAD shows the largest number of these associations.

The most reproducible SFN-associated genes across cancer lineages are COX15, CENPU, and SLC25A4. Each is linked with SFN in more than 1 cancer types. Because this analysis shows association rather than direction, both SFN-to-partner and partner-to-SFN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX15 grouped by SFN-low versus SFN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFN→partner) and Y-score (partner→SFN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COX15 →	+0.355	+2.708	.009	.003	3	2
COAD	CENPU →	+0.813	+4.247	<.001	<.001	3	2
UCEC	SLC25A4 →	+0.492	+2.724	.003	.003	3	2
UCEC	FAM151B →	+0.329	+2.294	<.001	.005	3	2
UCEC	ZNF776 →	+0.493	+2.202	.007	.001	3	2
UCEC	SAR1B →	+0.416	+2.526	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,806 associations by consensus.

COX15 by SFN expression — UCEC

Explore this box plot interactively →