SFN

Across TCGA patient cohorts, SFN mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. COAD shows the largest number of these associations.

The most reproducible SFN-associated genes across cancer lineages are INPP4B, ATM, and Chk2_pT68. Each is linked with SFN in more than 1 cancer types. Because this analysis shows association rather than direction, both SFN-to-partner and partner-to-SFN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by SFN-low versus SFN-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFN→partner) and Y-score (partner→SFN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INPP4B →	-0.450	-3.898	.002	<.001	3	2
UCEC	ATM →	-0.531	-3.087	.003	<.001	3	2
UCEC	Chk2_pT68 →	-0.147	-2.415	.049	.003	3	2
COAD	eEF2 →	+0.299	+3.169	.010	.018	3	1
COAD	eIF4E →	+0.181	+3.182	.009	.009	2	2
COAD	FASN →	+0.434	+2.123	.004	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

INPP4B by SFN expression — COAD

Explore this box plot interactively →