SFN

Across TCGA cell cohorts, SFN RNA expression is significantly associated with the go_rna of many other GO terms, with 3,270 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SFN-associated GO terms across cancer lineages are Regulation of epidermal cell division, Intermediate filament-based process, and Intermediate filament cytoskeleton organization. Each is linked with SFN in more than 12 cancer types. Because this analysis shows association rather than direction, both SFN-to-partner and partner-to-SFN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of epidermal cell division grouped by SFN-low versus SFN-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SFN→partner) and Y-score (partner→SFN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of epidermal cell division →	+1.910	+3.355	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Intermediate filament-based process →	+0.163	+2.371	<.001	.004	3	10
LUNG_NSCLC_LUSC	Intermediate filament cytoskeleton organization →	+0.162	+2.296	<.001	.006	3	10
URINARY_TRACT	Cell-substrate junction assembly →	+0.173	+2.639	<.001	<.001	3	10
OVARY	Establishment of skin barrier →	+0.296	+4.402	<.001	<.001	3	10
BREAST	Negative regulation of defense response →	+0.057	+2.026	.009	<.001	1	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,270 associations by consensus.

Regulation of epidermal cell division by SFN expression — KIDNEY

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