Across TCGA patient cohorts, SFI1 mutation is significantly associated with the RNA expression of many other genes, with 3,435 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFI1-associated genes across cancer lineages are PIMREG, MELK, and SKA3. Each is linked with SFI1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SFI1-to-partner and partner-to-SFI1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFI1→partner) and Y-score (partner→SFI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PIMREG →	+0.576	+1.699	.001	<.001	3	4
UCEC	MELK →	+0.512	+1.936	.004	.002	3	3
UCEC	SKA3 →	+0.407	+1.516	.005	.001	3	3
UCEC	TUBA1C →	+0.446	+3.031	.006	<.001	3	3
UCEC	PBK →	+0.649	+2.662	.001	<.001	3	3
UCEC	GON7 →	+0.356	+1.936	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,435 associations by consensus.

Exploration

SFI1 survival (RNA) · tumor vs normal (RNA) · all SFI1 data types