SF3B6

Across TCGA patient cohorts, SF3B6 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,162 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SF3B6-associated proteins across cancer lineages are MCM2, MCM3, and MCM7. Each is linked with SF3B6 in more than 7 cancer types. Because this analysis shows association rather than direction, both SF3B6-to-partner and partner-to-SF3B6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SF3B6 versus MCM2 in GBM, with a Pearson correlation of 0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3B6→partner) and Y-score (partner→SF3B6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MCM2 →	+0.629	+0.281	<.001	<.001	3	8
PDAC	MCM3 →	+0.634	+0.359	<.001	<.001	3	8
GBM	MCM7 →	+0.673	+0.334	<.001	<.001	3	8
LSCC	MPHOSPH10 →	+0.440	+0.610	<.001	<.001	3	8
BRCA	NCAPH →	+0.661	+0.475	<.001	<.001	3	7
LSCC	NOL11 →	+0.367	+0.613	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,162 associations by consensus.

SF3B6 vs MCM2 — GBM

Explore this scatter interactively →