SF3B5

Across TCGA patient cohorts, SF3B5 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible SF3B5-associated genes across cancer lineages are KRTAP9-11P, BCAR1P2, and GPR32P1. Each is linked with SF3B5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SF3B5-to-partner and partner-to-SF3B5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP9-11P grouped by SF3B5-low versus SF3B5-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3B5→partner) and Y-score (partner→SF3B5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	KRTAP9-11P →	+0.134	+7.924	<.001	.008	3	1
BLCA	BCAR1P2 →	+0.071	+4.788	<.001	.006	3	1
BLCA	GPR32P1 →	+0.319	+4.588	<.001	.008	3	1
BLCA	PABPC1P5 →	+0.054	+5.914	<.001	<.001	3	1
BLCA	BNIP3P36 →	+0.197	+5.064	<.001	.001	3	1
BLCA	OR6U2P →	+0.048	+5.018	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

KRTAP9-11P by SF3B5 expression — LUSC

Explore this box plot interactively →