SF3B5

Across TCGA pan-cancer cohorts, SF3B5 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SF3B5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SF3B5 RNA is repressed in tumor relative to normal tissue. In most cancer types SF3B5 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, LIHC, and HNSC are the cancer types where SF3B5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SF3B5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.311	<.001	9	view →
LIHC	Female	II,III,IV	+0.894	<.001	8	view →
HNSC	Male	All	+0.389	.004	7	view →
COAD	Female	All	+0.677	<.001	4	view →
STAD	All	II,III,IV	+0.373	.004	4	view →
CHOL	Male	All	+1.539	<.001	3	view →
LUSC	All	All	+0.325	<.001	3	view →
THCA	All	All	−0.232	.005	3	view →
UCEC	All	All	+0.310	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

SF3B5–KICH

Open the KICH breakdown →