Across TCGA patient cohorts, SF3B3 protein abundance is significantly associated with the RNA expression of many other genes, with 19,844 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SF3B3-associated genes across cancer lineages are MEX3A, RAE1, and HEATR1. Each is linked with SF3B3 in more than 8 cancer types. Because this analysis shows association rather than direction, both SF3B3-to-partner and partner-to-SF3B3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3B3→partner) and Y-score (partner→SF3B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MEX3A →	+1.439	+0.295	<.001	<.001	3	9
LSCC	RAE1 →	+0.631	+0.233	<.001	<.001	3	8
LSCC	HEATR1 →	+0.642	+0.218	<.001	<.001	3	8
LSCC	TROAP →	+0.876	+0.226	<.001	<.001	3	8
LSCC	USP21 →	+0.567	+0.212	<.001	<.001	3	8
HNSC	SRSF2 →	+0.592	+0.143	.008	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,844 associations by consensus.

Exploration

SF3B3 survival (RNA) · tumor vs normal (RNA) · all SF3B3 data types