Across TCGA cell cohorts, SF3B3 mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SF3B3-associated genes across cancer lineages are IQCF5, MS4A3, and POU4F2. Each is linked with SF3B3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SF3B3-to-partner and partner-to-SF3B3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3B3→partner) and Y-score (partner→SF3B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	IQCF5 →	+0.042	+4.357	<.001	.006	3	2
OESOPHAGUS	MS4A3 →	+0.093	+3.584	<.001	.008	3	1
OESOPHAGUS	POU4F2 →	+0.006	+3.857	<.001	.002	3	1
OESOPHAGUS	WFDC13 →	+0.068	+3.523	.004	.009	3	1
OESOPHAGUS	CDR1 →	+0.148	+3.392	.003	.007	3	1
OESOPHAGUS	CYP4A11 →	+0.032	+4.115	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Exploration

SF3B3 survival (RNA) · tumor vs normal (RNA) · all SF3B3 data types