SF3B2

Across TCGA patient cohorts, SF3B2 mutation is significantly associated with the RNA expression of many other genes, with 2,866 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SF3B2-associated genes across cancer lineages are KMT5AP1, RNA5SP423, and GMEB1. Each is linked with SF3B2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SF3B2-to-partner and partner-to-SF3B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KMT5AP1 grouped by SF3B2-low versus SF3B2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3B2→partner) and Y-score (partner→SF3B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	KMT5AP1 →	+0.127	+1.951	.002	.009	3	3
LUSC	RNA5SP423 →	+0.529	+5.148	<.001	.002	3	3
UCEC	GMEB1 →	+0.410	+2.559	<.001	<.001	3	3
UCEC	DDIAS →	+0.550	+2.329	.004	.003	3	3
UCEC	DHRS13 →	+0.623	+2.939	.003	<.001	3	3
UCEC	ZWILCH →	+0.646	+2.338	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,866 associations by consensus.

KMT5AP1 by SF3B2 expression — SKCM

Explore this box plot interactively →