SF3B1

Across TCGA pan-cancer cohorts, SF3B1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SF3B1 data layer compared with 23 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SF3B1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SF3B1 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

COAD, HNSC, and LUAD are the cancer types where SF3B1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.892	.028	12	view →
HNSC	OS	Quartile	All	0.755	0.925	.019	12	view →
LUAD	OS	Tertile	All	0.917	0.732	.015	6	view →
LSCC	OS	Tertile	II,III,IV	0.931	0.646	.030	2	view →
PDAC	DFS	Median	II,III,IV	0.704	0.846	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SF3B1–COAD (DFS)

Open the COAD breakdown →