SF3B1

Across TCGA patient cohorts, SF3B1 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SF3B1-associated genes across cancer lineages are ATM, Rad50, and ERCC1. Each is linked with SF3B1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SF3B1-to-partner and partner-to-SF3B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SF3B1-low versus SF3B1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3B1→partner) and Y-score (partner→SF3B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.679	-2.313	<.001	.035	3	5
UCEC	Rad50 →	-0.188	-1.321	.005	.005	3	3
BLCA	ERCC1 →	+0.147	+3.459	.031	.005	3	2
BLCA	TFRC →	+0.659	+2.182	.003	.033	3	2
BRCA	PDK1 →	+0.155	+2.335	.037	.021	3	2
BRCA	DJ-1 →	+0.276	+2.321	.020	.037	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

ATM by SF3B1 expression — COAD

Explore this box plot interactively →