SF3B1

Across TCGA cell cohorts, SF3B1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,187 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SF3B1-associated GO terms across cancer lineages are Late viral transcription, Protein localization to cytoplasmic stress granule, and Regulation of alternative mRNA splicing, via spliceosome. Each is linked with SF3B1 in more than 13 cancer types. Because this analysis shows association rather than direction, both SF3B1-to-partner and partner-to-SF3B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Late viral transcription grouped by SF3B1-low versus SF3B1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3B1→partner) and Y-score (partner→SF3B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Late viral transcription →	+0.158	+0.880	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Protein localization to cytoplasmic stress granule →	+0.147	+0.690	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of alternative mRNA splicing, via spliceosome →	+0.100	+0.753	.001	<.001	3	12
LIVER	Viral transcription →	+0.133	+0.599	<.001	.004	3	12
CNS	Medulla oblongata development →	+0.174	+0.535	.008	<.001	3	11
SOFT_TISSUE	Regulation of RNA splicing →	+0.112	+0.795	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,187 associations by consensus.

Late viral transcription by SF3B1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →