SF3A1

Across TCGA patient cohorts, SF3A1 mutation is significantly associated with the RNA expression of many other genes, with 1,155 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SF3A1-associated genes across cancer lineages are RN7SL785P, OR2J3, and NXT1P1. Each is linked with SF3A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SF3A1-to-partner and partner-to-SF3A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL785P grouped by SF3A1-low versus SF3A1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3A1→partner) and Y-score (partner→SF3A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL785P →	+0.153	+4.995	.003	.009	3	2
LIHC	OR2J3 →	+0.044	+6.149	<.001	.002	3	2
LIHC	NXT1P1 →	+0.173	+5.033	<.001	.009	3	2
LIHC	RN7SL97P →	+0.170	+5.878	<.001	.002	3	2
UCEC	C12orf43 →	+0.277	+3.733	.005	<.001	3	2
UCEC	HGSNAT →	-0.521	-2.874	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,155 associations by consensus.

RN7SL785P by SF3A1 expression — BRCA

Explore this box plot interactively →