SEZ6L

Across TCGA patient cohorts, SEZ6L mutation is significantly associated with the RNA expression of many other genes, with 4,909 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEZ6L-associated genes across cancer lineages are MIF, FAM177A1, and HAUS1. Each is linked with SEZ6L in more than 3 cancer types. Because this analysis shows association rather than direction, both SEZ6L-to-partner and partner-to-SEZ6L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIF grouped by SEZ6L-low versus SEZ6L-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEZ6L→partner) and Y-score (partner→SEZ6L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIF →	+0.804	+3.481	<.001	.002	3	4
UCEC	FAM177A1 →	+0.316	+2.769	<.001	<.001	3	4
COAD	HAUS1 →	+0.457	+2.624	<.001	.005	3	4
COAD	TSR1 →	+0.393	+1.847	<.001	.002	3	4
LUAD	RRM2 →	+0.743	+2.942	.003	<.001	3	4
UCEC	JKAMP →	+0.348	+2.408	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,909 associations by consensus.

MIF by SEZ6L expression — BLCA

Explore this box plot interactively →