SEZ6L

Across TCGA pan-cancer cohorts, SEZ6L RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SEZ6L’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SEZ6L RNA is repressed in tumor relative to normal tissue. In most cancer types SEZ6L is over-expressed in tumor, although a few such as COAD and STAD show the opposite, repressed pattern.

COAD, KICH, and STAD are the cancer types where SEZ6L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEZ6L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.530	<.001	12	view →
KICH	Female	All	+2.258	<.001	8	view →
STAD	All	All	−0.540	<.001	7	view →
KIRC	Male	All	+0.089	<.001	5	view →
LIHC	Male	All	−0.060	<.001	5	view →
READ	All	All	−0.640	.002	4	view →
BRCA	All	All	+0.433	.004	4	view →
HNSC	All	II,III,IV	−0.311	.010	4	view →
THCA	Male	II,III,IV	−0.231	<.001	3	view →
KIRP	Female	All	+0.103	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SEZ6L–COAD

Open the COAD breakdown →