SEZ6L

Across TCGA patient cohorts, SEZ6L mutation is significantly associated with the total protein of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEZ6L-associated genes across cancer lineages are 4E-BP1_pT37_T46, Caspase-7-cleavedD198, and ACC1. Each is linked with SEZ6L in more than 2 cancer types. Because this analysis shows association rather than direction, both SEZ6L-to-partner and partner-to-SEZ6L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT37_T46 grouped by SEZ6L-low versus SEZ6L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEZ6L→partner) and Y-score (partner→SEZ6L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1_pT37_T46 →	-0.273	-1.893	.020	.014	3	3
UCEC	Caspase-7-cleavedD198 →	+0.774	+2.999	<.001	<.001	3	3
UCEC	ACC1 →	+0.260	+1.584	.023	.005	3	3
UCEC	JNK2 →	+0.154	+1.353	.014	.015	3	3
LUSC	cIAP →	+0.255	+3.331	<.001	.005	3	3
LUAD	Cyclin-B1 →	+0.565	+3.459	.003	.005	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

4E-BP1_pT37_T46 by SEZ6L expression — UCEC

Explore this box plot interactively →