SEZ6L

Across TCGA cell cohorts, SEZ6L RNA expression is significantly associated with the go_rna of many other GO terms, with 1,122 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SEZ6L-associated GO terms across cancer lineages are Positive regulation of double-strand break repair, Protein K48-linked ubiquitination, and Positive regulation of defense response to bacterium. Each is linked with SEZ6L in more than 4 cancer types. Because this analysis shows association rather than direction, both SEZ6L-to-partner and partner-to-SEZ6L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair grouped by SEZ6L-low versus SEZ6L-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEZ6L→partner) and Y-score (partner→SEZ6L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of double-strand break repair →	+0.045	+1.616	.004	.007	3	5
LUNG_SCLC	Protein K48-linked ubiquitination →	+0.040	+2.130	.002	.002	3	4
LUNG_SCLC	Positive regulation of defense response to bacterium →	-0.343	-2.201	.001	<.001	3	3
LUNG_SCLC	Regulation of myoblast fusion →	+0.105	+2.894	.001	.002	3	3
BREAST	Negative regulation of calcium ion export across plasma membrane →	+0.068	+0.023	.008	.007	2	4
LUNG_SCLC	Regulation of cell proliferation involved in heart morphogenesis →	+0.138	+2.458	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,122 associations by consensus.

Positive regulation of double-strand break repair by SEZ6L expression — LUNG_SCLC

Explore this box plot interactively →