SEZ6L

Across TCGA cell cohorts, SEZ6L mutation is significantly associated with the RNA expression of many other genes, with 320 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEZ6L-associated genes across cancer lineages are LY6G6F, C12orf65, and LLGL1. Each is linked with SEZ6L in more than 1 cancer types. Because this analysis shows association rather than direction, both SEZ6L-to-partner and partner-to-SEZ6L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LY6G6F grouped by SEZ6L-low versus SEZ6L-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEZ6L→partner) and Y-score (partner→SEZ6L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	LY6G6F →	+0.040	+5.087	<.001	.004	3	2
LARGE_INTESTINE	C12orf65 →	+0.438	+3.082	.002	.007	3	2
LARGE_INTESTINE	LLGL1 →	+0.827	+3.389	.001	.001	3	2
LARGE_INTESTINE	MPRIP →	+0.920	+2.502	.001	.005	3	2
LARGE_INTESTINE	UQCC2 →	+0.469	+2.588	.009	.004	3	2
LARGE_INTESTINE	RAB28 →	+0.519	+3.237	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 320 associations by consensus.

LY6G6F by SEZ6L expression — URINARY_TRACT

Explore this box plot interactively →