SEZ6

Across TCGA cell cohorts, SEZ6 mutation is significantly associated with the RNA expression of many other genes, with 484 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEZ6-associated genes across cancer lineages are FAM149A, CFHR2, and CRCT1. Each is linked with SEZ6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEZ6-to-partner and partner-to-SEZ6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM149A grouped by SEZ6-low versus SEZ6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEZ6→partner) and Y-score (partner→SEZ6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FAM149A →	+1.036	+3.309	<.001	.006	3	2
BLOOD_Leukemia	CFHR2 →	+0.135	+3.539	<.001	.002	3	2
BLOOD_Lymphoma	CRCT1 →	+0.019	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	KRT73 →	+0.220	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	TFAP2D →	+0.074	+4.643	<.001	.005	3	1
BLOOD_Leukemia	PRRX1 →	+1.430	+3.245	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 484 associations by consensus.

FAM149A by SEZ6 expression — BLOOD_Leukemia

Explore this box plot interactively →