SETP4

Across TCGA patient cohorts, SETP4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,750 significant associations in total. COAD shows the largest number of these associations.

The most reproducible SETP4-associated GO terms across cancer lineages are 5S class rRNA transcription by RNA polymerase III, mRNA transport, and RNA localization. Each is linked with SETP4 in more than 22 cancer types. Because this analysis shows association rather than direction, both SETP4-to-partner and partner-to-SETP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 5S class rRNA transcription by RNA polymerase III grouped by SETP4-low versus SETP4-high in MESO.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SETP4→partner) and Y-score (partner→SETP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
MESO	5S class rRNA transcription by RNA polymerase III →	+0.061	+0.087	<.001	<.001	3	23
THYM	mRNA transport →	+0.038	+0.107	<.001	<.001	3	23
THYM	RNA localization →	+0.035	+0.098	<.001	<.001	3	23
TGCT	Regulation of mRNA catabolic process →	+0.026	+0.127	<.001	<.001	3	23
THYM	Peptidyl-lysine modification →	+0.028	+0.077	<.001	<.001	3	22
THYM	Positive regulation of mRNA 3'-end processing →	+0.048	+0.060	<.001	<.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,750 associations by consensus.

5S class rRNA transcription by RNA polymerase III by SETP4 expression — MESO

Explore this box plot interactively →