SETP4

Across TCGA pan-cancer cohorts, SETP4 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of SETP4’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where SETP4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SETP4 is over-expressed in tumor.

STAD, BLCA, and HNSC are the cancer types where SETP4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SETP4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	II,III,IV	+0.118	<.001	7	view →
BLCA	All	III,IV	+0.116	.002	4	view →
HNSC	All	II,III,IV	+0.051	.031	4	view →
LUAD	All	All	+0.083	.001	3	view →
LUSC	All	II,III,IV	+0.061	.013	2	view →
LIHC	Male	All	+0.026	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

SETP4–STAD

Open the STAD breakdown →