SETP16

Across TCGA pan-cancer cohorts, SETP16 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated SETP16 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher SETP16 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SETP16 expression acts as an unfavorable survival marker, although some lineages such as CESC and PRAD show a favorable association.

UVM, UCEC, and READ are the cancer types where SETP16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.178	0.947	<.001	54	view →
UCEC	DFS	Tertile	All	0.752	0.851	.008	48	view →
READ	OS	Tertile	All	0.719	0.925	.004	45	view →
THYM	OS	Tertile	All	0.319	0.912	<.001	42	view →
ESCA	DFS	Tertile	II,III,IV	0.303	0.910	.016	20	view →
PAAD	DFS	Tertile	III,IV	0.118	0.734	.014	18	view →
SKCM	DFS	Tertile	IV	0.036	0.433	<.001	18	view →
CESC	OS	Tertile	All	0.800	0.550	.035	18	view →
MESO	OS	Tertile	II,III,IV	0.247	0.569	.035	18	view →
BRCA	DFS	Tertile	All	0.484	0.558	.025	18	view →
TGCT	OS	Tertile	II,III,IV	0.752	1.000	.019	18	view →
ACC	OS	Tertile	All	0.232	0.649	.016	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

SETP16–UVM (OS)

Open the UVM breakdown →