SETP16

Across TCGA pan-cancer cohorts, SETP16 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SETP16’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SETP16 RNA is repressed in tumor relative to normal tissue. In most cancer types SETP16 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA, STAD, and BRCA are the cancer types where SETP16 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SETP16 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.081	.027	2	view →
STAD	Male	II,III,IV	+0.074	.006	2	view →
BRCA	All	All	+0.033	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

SETP16–THCA

Open the THCA breakdown →