SETP11

Across TCGA patient cohorts, SETP11 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,488 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SETP11-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Protein polyubiquitination, and Protein-containing complex disassembly. Each is linked with SETP11 in more than 13 cancer types. Because this analysis shows association rather than direction, both SETP11-to-partner and partner-to-SETP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by SETP11-low versus SETP11-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SETP11→partner) and Y-score (partner→SETP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Epigenetic regulation of gene expression →	+0.054	+0.229	<.001	<.001	3	14
STAD	Protein polyubiquitination →	+0.060	+0.247	<.001	<.001	3	14
STAD	Protein-containing complex disassembly →	+0.052	+0.240	<.001	<.001	3	14
STAD	Negative regulation of protein-containing complex disassembly →	+0.052	+0.217	<.001	<.001	3	13
STAD	Regulation of RNA splicing →	+0.063	+0.260	<.001	<.001	3	13
ESCA	Negative regulation of gene expression, epigenetic →	+0.065	+0.164	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,488 associations by consensus.

Epigenetic regulation of gene expression by SETP11 expression — STAD

Explore this box plot interactively →