SETP11

Across TCGA pan-cancer cohorts, SETP11 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SETP11’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SETP11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SETP11 is over-expressed in tumor, although a few such as ESCA show the opposite, repressed pattern.

KIRC, ESCA, and UCEC are the cancer types where SETP11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SETP11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.032	.012	3	view →
ESCA	Female	All	−0.396	<.001	2	view →
UCEC	All	IV	+0.210	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

SETP11–KIRC

Open the KIRC breakdown →