SETP10

Across TCGA pan-cancer cohorts, SETP10 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated SETP10 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher SETP10 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SETP10 expression acts as an unfavorable survival marker, although some lineages such as COAD and READ show a favorable association.

UVM, STAD, and COAD are the cancer types where SETP10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.317	0.938	<.001	54	view →
STAD	DFS	Median	II,III,IV	0.216	0.482	<.001	49	view →
COAD	DFS	Tertile	II,III,IV	0.961	0.450	<.001	36	view →
PRAD	OS	Tertile	All	0.634	0.919	<.001	36	view →
SKCM	DFS	Tertile	III,IV	0.275	0.579	.005	30	view →
READ	OS	Tertile	All	0.960	0.545	.028	30	view →
GBM	DFS	Median	All	0.328	0.207	.003	29	view →
ACC	DFS	Tertile	III,IV	0.050	0.471	.005	27	view →
MESO	DFS	Tertile	IV	0.073	0.381	<.001	27	view →
THCA	OS	Tertile	II,III,IV	0.893	0.971	.015	24	view →
OV	OS	Quartile	IV	0.611	0.910	.011	24	view →
TGCT	DFS	Tertile	III,IV	0.505	1.000	.016	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

SETP10–UVM (OS)

Open the UVM breakdown →