SETMAR

Across TCGA patient cohorts, SETMAR mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SETMAR-associated genes across cancer lineages are INPP4B, Rab25, and ATM. Each is linked with SETMAR in more than 1 cancer types. Because this analysis shows association rather than direction, both SETMAR-to-partner and partner-to-SETMAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by SETMAR-low versus SETMAR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETMAR→partner) and Y-score (partner→SETMAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.337	-3.584	.007	.002	3	2
UCEC	Rab25 →	-0.364	-3.321	.005	.009	3	2
UCEC	ATM →	-0.643	-2.687	<.001	.005	3	2
UCEC	4E-BP1 →	+0.324	+2.489	.002	.010	3	2
UCEC	EGFR_pY1068 →	-0.268	-3.321	.006	.009	3	1
UCEC	A-Raf_pS299 →	-0.133	-2.000	.004	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

INPP4B by SETMAR expression — UCEC

Explore this box plot interactively →