SETMAR

Across TCGA pan-cancer cohorts, SETMAR RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SETMAR data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher SETMAR RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SETMAR expression acts as an unfavorable survival marker, although some lineages such as DLBC and READ show a favorable association.

LIHC, DLBC, and READ are the cancer types where SETMAR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.715	0.834	.001	45	view →
DLBC	DFS	Tertile	All	1.000	0.416	.005	38	view →
READ	DFS	Tertile	II,III,IV	0.882	0.334	.004	37	view →
ACC	DFS	Median	All	0.247	0.782	<.001	33	view →
SKCM	DFS	Tertile	II,III,IV	0.222	0.505	.005	26	view →
UVM	DFS	Median	II,III,IV	0.735	0.422	.013	24	view →
BLCA	OS	Median	II,III,IV	0.681	0.548	.004	23	view →
KIRC	DFS	Median	All	0.735	0.534	.013	20	view →
SCLC	DFS	Median	II,III,IV	0.519	0.157	.007	14	view →
PAAD	OS	Quartile	All	0.712	0.414	.026	12	view →
LUAD	DFS	Quartile	All	0.887	0.735	.007	12	view →
LUSC	DFS	Median	III,IV	0.394	0.913	.002	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

SETMAR–LIHC (OS)

Open the LIHC breakdown →