SETMAR

Across TCGA cell cohorts, SETMAR RNA expression is significantly associated with the go_rna of many other GO terms, with 4,476 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SETMAR-associated GO terms across cancer lineages are DNA double-strand break processing, Regulation of double-strand break repair, and Positive regulation of double-strand break repair via nonhomologous end joining. Each is linked with SETMAR in more than 16 cancer types. Because this analysis shows association rather than direction, both SETMAR-to-partner and partner-to-SETMAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA double-strand break processing grouped by SETMAR-low versus SETMAR-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SETMAR→partner) and Y-score (partner→SETMAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DNA double-strand break processing →	+0.144	+1.732	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Regulation of double-strand break repair →	+0.075	+1.083	<.001	<.001	3	15
LUNG_SCLC	Positive regulation of double-strand break repair via nonhomologous end joining →	+0.090	+0.659	<.001	.001	3	15
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication maintenance of fidelity →	+0.105	+0.894	.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.134	+1.084	<.001	<.001	3	15
LIVER	Regulation of DNA repair →	+0.070	+1.245	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,476 associations by consensus.

DNA double-strand break processing by SETMAR expression — OESOPHAGUS

Explore this box plot interactively →