SETMAR

Across TCGA cell cohorts, SETMAR mutation is significantly associated with the RNA expression of many other genes, with 443 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SETMAR-associated genes across cancer lineages are SSX7, RASL10A, and ALKBH1. Each is linked with SETMAR in more than 1 cancer types. Because this analysis shows association rather than direction, both SETMAR-to-partner and partner-to-SETMAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSX7 grouped by SETMAR-low versus SETMAR-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETMAR→partner) and Y-score (partner→SETMAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SSX7 →	+0.433	+5.285	<.001	.003	3	1
LARGE_INTESTINE	RASL10A →	+0.259	+3.212	.006	.006	3	1
LARGE_INTESTINE	ALKBH1 →	+0.398	+3.212	.006	.006	3	1
LARGE_INTESTINE	NUBP1 →	+0.488	+3.212	.001	.006	3	1
LARGE_INTESTINE	AAGAB →	+0.457	+3.082	.002	.007	3	1
LARGE_INTESTINE	UBXN8 →	+0.937	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 443 associations by consensus.

SSX7 by SETMAR expression — STOMACH

Explore this box plot interactively →