SETDB1

Across TCGA patient cohorts, SETDB1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SETDB1-associated genes across cancer lineages are 4E-BP1_pT37_T46, eIF4E, and IGFBP2. Each is linked with SETDB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SETDB1-to-partner and partner-to-SETDB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT37_T46 grouped by SETDB1-low versus SETDB1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETDB1→partner) and Y-score (partner→SETDB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	4E-BP1_pT37_T46 →	-0.524	-3.000	.023	.036	3	3
UCEC	eIF4E →	+0.147	+2.515	.011	<.001	3	2
UCEC	IGFBP2 →	-0.650	-2.392	<.001	<.001	3	2
UCEC	Rad50 →	-0.138	-1.369	.038	.003	3	2
UCEC	ASNS →	+0.340	+1.353	<.001	.013	3	2
UCEC	ATM →	-0.424	-1.369	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

4E-BP1_pT37_T46 by SETDB1 expression — SKCM

Explore this box plot interactively →