SETDB1

Across TCGA cell cohorts, SETDB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,272 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SETDB1-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Positive regulation of double-strand break repair, and Regulation of nucleotide-excision repair. Each is linked with SETDB1 in more than 16 cancer types. Because this analysis shows association rather than direction, both SETDB1-to-partner and partner-to-SETDB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by SETDB1-low versus SETDB1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SETDB1→partner) and Y-score (partner→SETDB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Epigenetic regulation of gene expression →	+0.080	+1.143	<.001	<.001	3	17
SOFT_TISSUE	Positive regulation of double-strand break repair →	+0.076	+0.783	<.001	<.001	3	16
SOFT_TISSUE	Regulation of nucleotide-excision repair →	+0.111	+0.735	<.001	<.001	3	16
OVARY	Negative regulation of gene expression, epigenetic →	+0.065	+0.718	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	RNA catabolic process →	+0.076	+0.990	<.001	<.001	3	16
BONE	Transcription initiation-coupled chromatin remodeling →	+0.077	+0.838	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,272 associations by consensus.

Epigenetic regulation of gene expression by SETDB1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →